Medizinische Universität Graz - Research portal
Selected Publication:
Archelos, JJ; Fortwängler, T; Hartung, HP.
Attenuation of experimental autoimmune neuritis in the Lewis rat by treatment with an antibody to L-selectin.
Neurosci Lett. 1997; 235(1-2):9-12
Doi: 10.1016%2FS0304-3940%2897%2900692-7
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- Leading authors Med Uni Graz
- Archelos-Garcia Juan-Jose
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- Abstract:
- The leukocyte adhesion molecule L-selectin plays a key role in the initial steps of transendothelial migration of T cells and monocytes. In this study we investigated the role of L-selectin in the pathogenesis of experimental autoimmune neuritis (EAN) an animal model of the Guillain-Barré syndrome. EAN was induced in Lewis rats by sensitization with peripheral nerve myelin. Treatment with HRL3, a monoclonal antibody to L-selectin, efficiently suppressed clinical signs of EAN. Histological examination of the peripheral nervous system (PNS) revealed a marked reduction of inflammatory infiltrates and demyelination during treatment with HRL3. We conclude that L-selectin-dependent mechanisms are of pathophysiological relevance in EAN. Modulation of L-selectin in vivo could be a novel therapeutic approach to autoimmune diseases of the PNS.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Antibodies - therapeutic use
- Cauda Equina - pathology
- Cricetinae - pathology
- Demyelinating Diseases - pathology
- Female - pathology
- L-Selectin - immunology
- Macrophages - immunology
- Neuritis, Autoimmune, Experimental - prevention and control
- Rats - prevention and control
- Rats, Inbred Lew - prevention and control
- Sciatic Nerve - pathology
- Spinal Nerves - pathology
- T-Lymphocytes - immunology
- Find related publications in this database (Keywords)
- Experimental Autoimmune Neuritis
- Autoimmune Disease
- Adhesion Molecules
- Peripheral Nervous System
- Therapy