Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Leitner, GC; Roob, JM; Bahadori, B; Wallner, S; Wascher, TC.
Leptin deficiency due to lipid apheresis: a possible reason for ravenous hunger and weight gain.
Int J Obes Relat Metab Disord. 2000; 24(2):259-260
Doi: 10.1038/sj.ijo.0801160
(- Case Report)
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- Führende Autor*innen der Med Uni Graz
- Leitner Gerhard
- Co-Autor*innen der Med Uni Graz
- Holasek Sandra Johanna
- Roob Johannes
- Wascher Thomas
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- Abstract:
- OBJECTIVE: To investigate how extracorporal cholesterol lowering therapy affects circulating leptin levels in patients with ravenous hunger after treatment and permanent weight gain. DESIGN: A case report. SUBJECT: 51 y old caucasian male patient with moderate chronic renal failure. MEASUREMENTS: Serum Leptin concentration (RIA, Linco Research Inc, St. Louis, MO, USA), total cholesterol, low density lipoprotein cholesterol, blood glucose levels, calorie intake by food records. RESULTS: During treatment total cholesterol was reduced by 50%. Serum Leptin levels showed a 42% reduction at the end of treatment, that by far exceeds the physiological diurnal variation. Calorie intake was significantly increased on days of treatment. CONCLUSION: We conclude that this artificial reduction in circulating leptin plays an important role in the pathogenesis of ravenous hunger and weight gain under extracorporal cholesterol lowering therapy in this case.
- Find related publications in this database (using NLM MeSH Indexing)
- Blood Glucose - analysis
- Cholesterol - blood
- Cholesterol, LDL - blood
- Energy Intake - physiology
- Humans - physiology
- Hunger - physiology
- Hyperlipidemias - blood
- Leptin - blood
- Male - blood
- Middle Aged - blood
- Plasmapheresis - adverse effects
- Weight Gain - adverse effects
- Find related publications in this database (Keywords)
- lipidapheresis
- leptin
- cholesterol
- appetite
- obesity