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Selected Publication:
Zhu, F; Schneditz, D; Kaufman, AM; Levin, NW.
Estimation of body fluid changes during peritoneal dialysis by segmental bioimpedance analysis.
Kidney Int. 2000; 57(1):299-306
Doi: 10.1046/j.1523-1755.2000.00815.x
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- Schneditz Daniel
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- Abstract:
- Estimation of body fluid changes during peritoneal dialysis by segmental bioimpedance analysis. BACKGROUND: Commonly used bioimpedance analysis (BIA) is insensitive to changes in peritoneal fluid volume. The purpose of this study was to show, to our knowledge for the first time, that a new segmental approach accurately measures extracellular fluid changes during peritoneal dialysis (PD). METHODS: Fourteen stable PD patients were studied during a standard exchange with fluids of known conductivity. Bioimpedance was continuously measured in the arm, trunk, and leg and from wrist to ankle. Volume changes were calculated using both a newly developed sum of segmental BIA (SBIA) and current wrist-to-ankle BIA (WBIA) and were compared with actual volume changes measured gravimetrically. RESULTS: When 2.19 +/- 0.48 L were removed from the peritoneal cavity during draining, 95.2 +/- 13.8% of this volume was detected by SBIA compared with only 12.5 +/- 24. 3% detected by WBIA. When 2.11 +/- 0.20 L of fresh dialysate was infused into the peritoneal cavity during filling, 91.1 +/- 19.6% of this volume was detected by SBIA compared with only 8.8 +/- 21.1% detected by WBIA. CONCLUSION: The good agreement between measured and calculated data using SBIA was due to: (a) improved placement of electrodes, (b) estimation of trunk extracellular volume based on a new algorithm, and (c) consideration of changes in dialysate conductivity. Correct estimation of fluid volume in the trunk is a prerequisite for applications in which direct analysis of fluid changes cannot be performed such as with peritoneal equilibration tests and continuous flow PD.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Body Fluids -
- Electric Impedance -
- Female -
- Humans -
- Male -
- Middle Aged -
- Peritoneal Dialysis -
- Find related publications in this database (Keywords)
- dialysis adequacy
- conductivity
- extracellular volume
- regional fluid distribution
- peritoneal equilibrium