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Selected Publication:
Klintschar, M; Beham-Schmidt, C; Radner, H; Henning, G; Roll, P.
Colchicine poisoning by accidental ingestion of meadow saffron (Colchicum autumnale): pathological and medicolegal aspects.
Forensic Sci Int. 1999; 106(3):191-200
Doi: 10.1016%2FS0379-0738%2899%2900191-7
(- Case Report)
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- Co-authors Med Uni Graz
- Beham-Schmid Christine
- Henning Gerald
- Roll Peter
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- Abstract:
- Although intoxications with colchicine, the alkaloid of Colchicum autumnale (meadow saffron), are well known, in most cases the intoxications are evoked by oral or parenteral preparations traditionally used as medication against gout. The accidental ingestion of Colchicum autumnale, on the other hand, is a rare event and has to our knowledge only twice been described in detail. We report a further case in which two persons confused this highly poisonous plant with wild garlic (Allium ursinum), a popular spice in the Central European cuisine. While one person merely complained about a 3-day episode of nausea, vomiting and watery diarrhea, the second person died of multi-organ system derangements 48 h after the ingestion of the colchicum leaves. At autopsy hemorrhagic lung oedema, hypocellular bonemarrow, centrilobular fatty necrosis of the liver and necrosis of the proximal convoluted tubuli of the kidneys were observed. A colchicine concentration of 7.5 micrograms/ml was found in the bile whereas no substance was detected in the postmortem blood.
- Find related publications in this database (using NLM MeSH Indexing)
- Accidents -
- Adult -
- Austria -
- Autopsy -
- Colchicine - analysis
- Colchicum - chemistry
- Diarrhea - chemically induced
- Fatal Outcome - chemically induced
- Female - chemically induced
- Humans - chemically induced
- Male - chemically induced
- Middle Aged - chemically induced
- Multiple Organ Failure - chemically induced
- Nausea - chemically induced
- Plants, Medicinal - chemically induced
- Time Factors - chemically induced
- Vomiting - chemically induced
- Find related publications in this database (Keywords)
- colchicine
- Colchicum autumnale
- plant poisoning
- toxicology
- pathology