Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Beham, A; Beham-Schmid, C; Regauer, S; Auböck, L; Stammberger, H.
Nasopharyngeal angiofibroma: true neoplasm or vascular malformation?
ADV ANAT PATHOL. 2000; 7(1): 36-46.
Doi: 10.1097/00125480-200007010-00006
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- Führende Autor*innen der Med Uni Graz
- Beham Alfred
- Co-Autor*innen der Med Uni Graz
- Beham-Schmid Christine
- Regauer Sigrid
- Stammberger Heinz
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- Abstract:
- Nasopharyngeal angiofibromas (NA) are rare tumor-like lesions characterized by architecturally irregular vessels set in a fibrous stroma. The unique morphology, the strong predilection for male adolescents, and the uncertainty about its etiology contributes to significant confusion regarding the classification of NA, which still has not been solved today. Based on immunohistochemical and electron microscopic examinations, we demonstrate in detail the various unusual vascular architectural features of NA. They represent discontinuous vascular basal laminae, focal lack of pericytes, and pronounced irregularity of the smooth muscle layers. In thick smooth muscle layers and pads, the orientation of muscle cells is frequently disturbed, and the individual cells differ in size and shape. Occasionally, the muscle layers disperse peripherally into individual cells, creating the impression of vessel-independent smooth muscle cells within the stroma. The summation of all morphological irregularities demonstrated in this paper allows the conclusion that NA represent vascular malformations.
- Find related publications in this database (using NLM MeSH Indexing)
- Actins - analysis
- Adolescent - analysis
- Angiofibroma - blood supply
- Blood Vessels - abnormalities
- Diagnosis, Differential - abnormalities
- Humans - abnormalities
- Male - abnormalities
- Muscle, Smooth, Vascular - chemistry
- Nasopharyngeal Neoplasms - blood supply
- Stromal Cells - chemistry
- Find related publications in this database (Keywords)
- nasopharyngeal angiofibroma immunohistochemistry
- electron microscopy
- smooth muscle layer
- vascular architecture
- vascular malformation