Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Pummer, K; Schmid, H; Trummer, H; Augustin, H; Hubmer, G.
Hormonal therapy of prostate cancer: is there any news?
Urol Int. 1999; 63(1):80-85
Doi: 10.1159/000030422
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Pummer Karl
- Co-Autor*innen der Med Uni Graz
- Augustin Herbert
- Hubmer Gerhart
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- Abstract:
- Androgen ablative therapy was introduced in the early 1940s and, even today, has remained the golden standard for the treatment of advanced prostate cancer. During the past decades, a variety of improvements have been achieved which, however, primarily aimed at a better tolerance or improved acceptance of androgen deprivation. However, after almost six decades of hormonal therapy it is appropriate to ask whether progress was also made in terms of efficacy, particularly as far as prolongation of survival or quality of life is concerned. During the last few years, two therapeutic strategies, maximal androgen blockade and intermittent androgen suppression, have been considered true conceptual advances. However, despite tremendous efforts and a huge number of studies so far, these concepts appear to produce more questions rather than answers. Therefore, it seems appropriate to raise some critical issues of maximal androgen blockade and intermittent androgen suppression.
- Find related publications in this database (using NLM MeSH Indexing)
- Androgen Antagonists - therapeutic use
- Antineoplastic Agents, Hormonal - therapeutic use
- Castration - therapeutic use
- Disease-Free Survival - therapeutic use
- Humans - therapeutic use
- Male - therapeutic use
- Prostatic Neoplasms - mortality
- Find related publications in this database (Keywords)
- new concepts of hormonal therapy
- maximal androgen blockade
- intermittent androgen suppression