Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Heinemann, A; Stauber, RE.
Vasodilator responses to nitric oxide are enhanced in mesenteric arteries of portal hypertensive rats.
Eur J Clin Invest. 1996; 26(9):824-826
Doi: 10.1046%2Fj.1365-2362http://dx.doi.org/10.1046%2Fj.1365-2362.1996.2340557.x
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- Führende Autor*innen der Med Uni Graz
- Heinemann Akos
- Co-Autor*innen der Med Uni Graz
- Stauber Rudolf
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- Abstract:
- Nitric oxide (NO) is discussed as a mediator of the splanchnic hyperaemia in portal hypertension. We assessed the vasorelaxation by the NO-dependent vasodilator acetylcholine, the NO donor 3-morpholino-sydnonimine (SIN-1) and forskolin, a stimulator of the adenylate cyclase pathway in potassium-preconstricted isolated perfused mesenteric arteries of portal vein-ligated and sham-operated rats. Dilator responses to acetylcholine and SIN-1 were significantly enhanced in vessels of portal vein-ligated rats as compared to sham-operated rats, whereas no difference was found in forskolin-induced vasodilatation. This suggests enhanced reactivity of the vasculature to NO in experimental portal hypertension.
- Find related publications in this database (using NLM MeSH Indexing)
- Acetylcholine - pharmacology
- Animals - pharmacology
- Dose-Response Relationship, Drug - pharmacology
- Hypertension, Portal - physiopathology
- Male - physiopathology
- Mesenteric Arteries - drug effects
- Molsidomine - analogs and derivatives
- Nitric Oxide - pharmacology
- Rats - pharmacology
- Rats, Sprague-Dawley - pharmacology
- Vasodilation - drug effects
- Vasodilator Agents - pharmacology
- Find related publications in this database (Keywords)
- Acetylcholine
- Forskolin
- 3-Morpholino-Sydnonimine (Sin-1)
- Nitric Oxide
- Portal Hypertensive Rats
- Vasodilatation