Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Ferrara, G; Argenziano, G; Soyer, HP; Chimenti, S; Di Blasi, A; Pellacani, G; Peris, K; Piccolo, D; Rubegni, P; Seidenari, S; Staibano, S; Zalaudek, I; De Rosa, G.
The spectrum of Spitz nevi: a clinicopathologic study of 83 cases.
Arch Dermatol. 2005; 141(11):1381-1387
Doi: 10.1001/archderm.141.11.1381
[OPEN ACCESS]
Web of Science
PubMed
FullText
FullText_MUG
Google Scholar
- Führende Autor*innen der Med Uni Graz
- Soyer Hans Peter
- Co-Autor*innen der Med Uni Graz
- Zalaudek Iris
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- Objective: To achieve a clinicopathologic classification of Spitz nevi by comparing their clinical, dermoscopic, and histopathologic features. Design: Eighty-three cases were independently reviewed by 3 histopathologists and preliminarily classified into classic or desmoplastic Spitz nevus (CDSN, n = 11), pigmented Spitz nevus (PSN, n = 14), Reed nevus (RN, n = 16), or atypical Spitz nevus (ASN, n = 14); the remaining 28 cases were then placed into an intermediate category (pigmented Spitz-Reed nevus, PSRN) because a unanimous diagnosis of either PSN or RN was not reached. Setting: University dermatology and pathology departments and general hospital pathology departments. Patients: A sample of subjects with excised melanocytic lesions. Main Outcome Measure: Frequency of dermoscopic patterns within the different histopathologic subtypes of Spitz nevi. Results: Overlapping clinical, dermoscopic, and histopathologic findings were observed among PSN, RN, and PSRN, thereby justifying their inclusion into the single PSRN diagnostic category. Asymmetry was the most frequent indicator of histopathologic ASN (79%; n = 11); in only 4 cases did dermoscopic asymmetry show no histopathologic counterpart, and in those cases the discrepancy was probably the result of an artifact of the gross sampling technique carried out with no attention to the dermoscopic. features. Conclusions: Among Spitz nevi, histopathologic distinction between PSN and. RN is difficult, not reproducible, and may be clinically useless. A simple clinicopathologic classification of these neoplasms might therefore be structured as CDSN, PSRN, and ASN. Asymmetry should be assessed using both dermoscopic and histopathologic analysis, and reliability in histopathologic diagnosis may be enhanced by the simultaneous evaluation of the corresponding dermoscopic images.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Child -
- Child, Preschool -
- Dermoscopy -
- Female -
- Humans -
- Infant -
- Infant - epidemiology
- Male -
- Medical Records -
- Middle Aged -
- Nevus, Epithelioid and Spindle Cell - diagnosis
- Retrospective Studies -
- Skin Neoplasms - diagnosis