Medizinische Universität Graz - Research portal

Go directly to the nagivation.
Go directly to the content.

Navigation/Search

Selected Publication:

Tronnier, M; Smolle, J; Wolff, HH.
Ultraviolet irradiation induces acute changes in melanocytic nevi.
J Invest Dermatol. 1995; 104(4):475-478 Doi: 10.1111%2F1523-1747.ep12605910 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG Google Scholar

Co-authors Med Uni Graz: Smolle Josef
Altmetrics:
Dimensions Citations:
Plum Analytics:
Scite (citation analytics):
Abstract:: Ultraviolet (UV) light represents one of the factors that might play a role in the initiation and promotion of malignant transformation of human melanocytes. To determine the short-term effects of UV irradiation on melanocytic nevi in vivo, we investigated one half of symmetric melanocytic nevi after a single UV exposure with double the patient's minimal erythema dose. This half was compared with the nonirradiated, shielded half of the same nevus. The different parts were examined histologically for differences and immunohistochemically for the presence of HMB-45 antigen and proliferating cell nuclear antigen. The features were assessed quantitatively by image analysis. One week after the single UV irradiation, we observed a significant increase of suprabasally located melanocytes and a markedly enhanced expression of HMB-45, whereas proliferative activity of the cells was unchanged. In nevi that were excised 2 or 3 weeks after irradiation, no significant differences were observed between the irradiated and the nonirradiated part. The results indicate that a single UV irradiation may induce transient melanocytic activation with morphologic and histologic changes. Although these data do not formally assess resemblance to melanoma, these changes may be similar to those of melanoma in situ.
Find related publications in this database (using NLM MeSH Indexing): Adolescent -; Adult -; Cell Division - radiation effects; Female - radiation effects; Humans - radiation effects; Keratinocytes - drug effects; Male - drug effects; Melanocytes - drug effects; Middle Aged - drug effects; Neoplasm Proteins - analysis; Nevus, Pigmented - pathology; Ultraviolet Rays - pathology
Find related publications in this database (Keywords): Nevus; Image Analysis; Histology