Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Gugatschka, M; Dobnig, H; Fahrleitner-Pammer, A; Pietschmann, P; Kudlacek, S; Strele, A; Obermayer-Pietsch, B.
Molecularly-defined lactose malabsorption, milk consumption and anthropometric differences in adult males.
QJM. 2005; 98(12):857-863
Doi: 10.1093/qjmed/hci140
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- Führende Autor*innen der Med Uni Graz
- Gugatschka Markus
- Co-Autor*innen der Med Uni Graz
- Dobnig Harald
- Fahrleitner-Pammer Astrid
- Groselj-Strele Andrea
- Obermayer-Pietsch Barbara
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- Abstract:
- BACKGROUND: Lactose malabsorption (LM) may be associated with reduced skeletal calcium content. Diagnosis to date has been based on indirect methods, with a high false-negative rate. Identification of the LCT polymorphism led to development of a PCR-based test. AIM: To evaluate the PCR-based test compared to a combination the hydrogen breath test and the lactose tolerance test, and investigate anthropometrical differences, changes in bone mineral density and oral calcium intake according to LCT polymorphism and milk-drinking habits. METHODS: All participants (n = 278) underwent clinical examination, with measurement of height, weight and bone density (DXA), and were genotyped for LCT polymorphism (LCT CC or LCT TT: CC is associated with LM). A subgroup (n = 51) had a hydrogen breath test and a lactose tolerance test, in addition to genotyping. RESULTS: Detection of LM by LCT polymorphism was highly significant (p = 0.001). The correlation between LCT genotype and self-reported milk-intolerance or dislike of milk with was slight, but the correlation with functional tests was highly significant. Non-milk-drinkers were lighter (-5 kg) and significantly shorter (-4 cm) than milk-drinkers (p = 0.07 and 0.04, respectively). Total calcium consumption was lower among non-milk-drinkers by about 18% (p = 0.03). DISCUSSION: Genotyping is an economic, quick and convenient method for diagnosing lactose malabsorption, with results comparable to existing tests. Sufficient calcium consumption may be relevant to body growth, as milk-drinkers were taller. Negative calcium bone balance may be prevented when provision is made for adequate calcium intake.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Aged, 80 and over -
- Animals -
- Body Height - physiology
- Body Weight - physiology
- Bone Density - physiology
- Breath Tests - methods
- Calcium, Dietary - administration and dosage
- Chromosomes, Human, Pair 2 - genetics
- Drinking - physiology
- Genotype - physiology
- Humans - physiology
- Hydrogen - analysis
- Lactose Intolerance - diagnosis
- Lactose Tolerance Test - methods
- Male - methods
- Middle Aged - methods
- Milk - methods
- Polymerase Chain Reaction - methods
- Polymorphism, Genetic - methods
- Sensitivity and Specificity - methods