Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Haire, RN; Ohta, Y; Lewis, JE; Fu, SM; Kroisel, P; Litman, GW.
TXK, a novel human tyrosine kinase expressed in T cells shares sequence identity with Tec family kinases and maps to 4p12.
Hum Mol Genet. 1994; 3(6):897-901
Doi: 10.1093/hmg/3.6.897
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- Co-Autor*innen der Med Uni Graz
- Kroisel Peter
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- Abstract:
- A gene for a novel, putative cytoplasmic tyrosine kinase, TXK has been isolated from a human peripheral blood cDNA library. The complete nucleotide sequence of the cDNA indicates that it is related most closely to EMT, a tyrosine kinase of T cells and to the B-cell tyrosine kinase Btk, which is mutated in X-linked agammaglobulinemia (XLA) in humans and X-linked immunodeficiency disease (XID) in mouse. TXK, like BTK, is a member of the Tec sub-family of Src-type (non-receptor) tyrosine kinases. Like similar Tec sub-family members, and unlike the other Src kinases, TXK lacks both the N-terminal myristylation signal and the C-terminal regulatory tyrosine. TXK expression is detected primarily in T cells and some myeloid cell lines but not in a number of other cell types. TXK shares 60% amino acid homology with EMT and 57% with BTK over the SH3, SH2 (Src-homology) and catalytic domains but unlike BTK, EMT and tec, it lacks Gap 1 homology and steroid hormone receptor homology in the N-terminal region. Genomic clones containing TXK have been isolated and hybridize to chromosome position 4p12.
- Find related publications in this database (using NLM MeSH Indexing)
- Amino Acid Sequence -
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- Bone Marrow - enzymology
- Cells, Cultured - enzymology
- Chromosome Mapping - enzymology
- Chromosomes, Human, Pair 4 - enzymology
- DNA Primers - enzymology
- Gene Library - enzymology
- Humans - enzymology
- Karyotyping - enzymology
- Molecular Sequence Data - enzymology
- Oligonucleotide Probes - enzymology
- Polymerase Chain Reaction - enzymology
- Protein-Tyrosine Kinases - biosynthesis
- Reference Values - biosynthesis
- Sequence Homology, Amino Acid - biosynthesis
- T-Lymphocytes - enzymology