Medizinische Universität Graz - Research portal
Selected Publication:
Magometschnigg, D; Brandt, D; Hofmann, R; Sihorsch, K; Stoschitzky, K; Zangeneh, M; Zenker, G.
Treatment of left ventricular hypertrophy in hypertensive patients with a combination of verapamil and captopril--a multicenter study.
Int J Clin Pharmacol Ther. 1997; 35(9):389-396
Web of Science
PubMed
- Co-authors Med Uni Graz
- Stoschitzky Kurt
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- Abstract:
- The regression of left ventricular hypertrophy in hypertensive patients was evaluated in a multicenter study with a combination therapy of verapamil 120 mg and captopril 25 mg given once or twice daily. The degree of left ventricular hypertrophy was assessed using echocardiography, while hypertension was evaluated by means of twice daily blood pressure self-measurements and ambulatory blood pressure monitoring. RESULTS: An overall of 61 patients was evaluated. Left ventricular mass had decreased by 13.5% during the 6-month treatment period. This reduction neither correlated with the baseline left ventricular mass nor with the extent of blood pressure decrease. CONCLUSION: The combination therapy-verapamil 120 mg plus captopril 25 mg--is well tolerated by hypertensive patients with left ventricular hypertrophy and produced a decrease of left ventricular mass that is independent of the extent of blood pressure decrease.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Angiotensin-Converting Enzyme Inhibitors - therapeutic use
- Antihypertensive Agents - therapeutic use
- Blood Pressure - drug effects
- Calcium Channel Blockers - therapeutic use
- Captopril - administration and dosage
- Drug Therapy, Combination - administration and dosage
- Electrocardiography - drug effects
- Female - drug effects
- Heart Rate - drug effects
- Humans - drug effects
- Hypertension - complications
- Hypertrophy, Left Ventricular - complications
- Male - complications
- Middle Aged - complications
- Myocardium - pathology
- Verapamil - administration and dosage
- Find related publications in this database (Keywords)
- Verapamil and Captopril
- Hypertension
- Left Ventricular Hypertrophy
- Echocardiography
- Blood Pressure Self-Measurement
- Ambulatory Blood Pressure Monitoring