Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Schwinger, W; Urban, C; Lackner, H; Mache, C.
Treatment of aplastic anemia with a monoclonal antibody directed against the interleukin-2 receptor.
Ann Hematol. 1993; 66(4):181-184
Doi: 10.1007/BF01703233
(- Case Report)
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- Führende Autor*innen der Med Uni Graz
- Schwinger Wolfgang
- Co-Autor*innen der Med Uni Graz
- Lackner Herwig
- Mache Christoph
- Urban Ernst-Christian
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- Abstract:
- Severe aplastic anemia (SAA) has been related in most cases to underlying autoimmune conditions. Various immunosuppressive regimens have been recommended in the absence of an HLA-identical bone marrow donor. Prednisolone, antithymocyte globulin, and cyclosporin A have been shown to be effective. This report describes the successful treatment of a 23-year-old woman suffering from severe aplastic anemia who had become multiresistant against previously administered immunosuppressive agents, using a monoclonal IL-2-receptor blocking antibody. The patient responded within 4 weeks. The time to the next relapse was 8 months; however, another remission with a second course of horse-antithymocyte globulin was achieved and has been maintained for 27 months to date with low doses of cyclosporin A. Although this is an anecdotical report, IL-2-receptor blockade using a monoclonal antibody might be considered as a further alternative in multi-resistant SAA, perhaps increasing the susceptibility to further immunosuppressive trials.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Anemia, Aplastic - blood
- Antibodies, Monoclonal - therapeutic use
- Cyclosporine - therapeutic use
- Female - therapeutic use
- Humans - therapeutic use
- Injections, Intravenous - therapeutic use
- Methylprednisolone - therapeutic use
- Receptors, Interleukin-2 - immunology
- Recurrence - immunology
- Find related publications in this database (Keywords)
- Aplastic Anemia
- Immunosuppressive Therapy
- IL-2-Receptor Antibody