Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Trauner, M; Fickert, P; Stauber, RE.
New molecular aspects of cholestatic liver diseases.
Z Gastroenterol. 1999; 37(7):639-647
Web of Science
PubMed
- Führende Autor*innen der Med Uni Graz
- Trauner Michael
- Co-Autor*innen der Med Uni Graz
- Fickert Peter
- Stauber Rudolf
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- Abstract:
- Hepatic uptake and biliary excretion of bile salts and non-bile salt organic anions (e.g., bilirubin) is mediated by specific transport proteins located at the basolateral and canalicular membranes of hepatocytes. Several hepatobiliary transport systems have been identified and cloned over the past years. This development has facilitated molecular biological and genetic analyses of these transporters in experimental cholestasis and human cholestatic liver diseases. Evidence now exists that decreased or even absent expression of hepatobiliary transport systems may explain impaired transport function resulting in hyperbilirubinemia and cholestasis. This review summarizes the molecular defects in hepatocellular membrane transporters associated with hereditary and acquired forms of cholestatic liver diseases. The increasing information on the molecular regulation of hepatobiliary transport systems should bring new insights into the pathophysiology and treatment of human cholestatic liver diseases.
- Find related publications in this database (using NLM MeSH Indexing)
- ATP-Binding Cassette Transporters - genetics
- Bile Acids and Salts - metabolism
- Bilirubin - metabolism
- Carrier Proteins - genetics
- Cholestasis - diagnosis Cholestasis - genetics
- Humans -
- Liver Cirrhosis, Biliary - diagnosis Liver Cirrhosis, Biliary - genetics
- P-Glycoproteins - genetics
- Point Mutation -
- Find related publications in this database (Keywords)
- bile acids
- transporters
- hepatocyte
- cholestasis
- ursodeoxycholic acid