Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Sametz, W; Prasthofer, S; Wintersteiger, R; Juan, H.
Vascular effects of isoprostanes after endothelial damage.
Prostaglandins Leukot Essent Fatty Acids. 1999; 61(6):369-372
Doi: 10.1054%2Fplef.1999.0113
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PubMed
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- Co-Autor*innen der Med Uni Graz
- Juan Heinz
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- Abstract:
- The isoprostanes, 8-iso-PGF2alpha and 8-iso-PGE2, are powerful vasoconstrictors in vitro and in vivo. Increased formation of 8-iso-PGF2alpha was detected in atherosclerotic patients. In this disease endothelial injuries appear, followed by a reduced release of nitric oxide (NO). Our results show that the vasoconstrictor effects of 8-iso-PGF2alpha as well as of 8-iso-PGE2 were amplified after endothelial damage of the vasculature of the isolated perfused rabbit ear. Also vasoconstrictions induced by both isoprostanes were amplified by perfusions with the NO-synthase blocker N(G)-nitro-L-arginine methylester (L-NAME) at a final concentration of 100 micromol/l. Therefore, we can assume that the amplification of the vasoconstrictor effects of the isoprostanes used after damage of endothelium might be mainly due to the reduced formation of NO.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Dinoprost - analogs and derivatives
- Dinoprostone - analogs and derivatives
- Dose-Response Relationship, Drug - analogs and derivatives
- Ear, External - blood supply
- Endothelium, Vascular - injuries
- F2-Isoprostanes - injuries
- Female - injuries
- Isomerism - injuries
- Isoprostanes - injuries
- Male - injuries
- NG-Nitroarginine Methyl Ester - pharmacology
- Rabbits - pharmacology
- Vasoconstriction - drug effects
- Vasoconstrictor Agents - pharmacology