Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Schmidt, HH; Pirc-Danoewinata, H; Panzer-Grümayer, ER; Sill, H; Sedlmayr, P; Neumeister, P; Linkesch, W; Haas, OA.
Translocation (3;5)(p26;q13) in a patient with chronic T-cell lymphoproliferative disorder.
Cancer Genet Cytogenet. 1998; 104(2):82-85
Doi: 10.1016/S0165-4608(97)00453-6
(- Case Report)
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Schmidt Helmut
- Co-Autor*innen der Med Uni Graz
- Linkesch Werner
- Neumeister Peter
- Sedlmayr Peter
- Sill Heinz
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- Abstract:
- A 67-year-old patient with large granular lymphocyte (LGL) leukemia is described. At fluorescence-activated cell sorting (FACS) analysis of the peripheral blood, the lymphocytes were positive for CD3, CD4, CD5, CD29, CD45RA, CD57, and TCR alpha/beta and negative for CD7, CD8, CD16, CD56, CD19, CD22, and TCR gamma/delta. Bone marrow histology and immunohistochemistry did not reveal any lymphocyte infiltration. Cytogenetic examination of peripheral blood cultures showed a clone with the karyotype 46,XY,t(3;5)(p26;q13). Molecular analysis revealed rearrangement of the gamma-T-cell-receptor chain. The region 3p25-3p26 which harbors the von Hippel-Lindau tumor suppressor gene and the RAF1 oncogene has been rearranged in a few cases of T-cell leukemia. The translocation in this case has not yet been described and may reflect an alternative mechanism in the pathogenesis of these disorders.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Antigens, CD - immunology
- Chromosomes, Human, Pair 3 -
- Chromosomes, Human, Pair 5 -
- Humans -
- Immunophenotyping -
- In Situ Hybridization, Fluorescence -
- Karyotyping -
- Leukemia, Lymphoid - genetics
- Male -
- Translocation, Genetic -