Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Schumacher, M; Eber, B; Tatzber, F; Kaufmann, P; Halwachs, G; Fruhwald, FM; Zweiker, R; Esterbauer, H; Klein, W.
Transient reduction of autoantibodies against oxidized LDL in patients with acute myocardial infarction.
Free Radic Biol Med. 1995; 18(6):1087-1091
Doi: 10.1016/0891-5849(94)00216-7
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Schumacher Martin
- Co-Autor*innen der Med Uni Graz
- Baumann Gabriele
- Fruhwald Friedrich
- Tatzber Franz
- Zweiker Robert
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- Abstract:
- Fifteen consecutive patients (mean age 66 +/- 14, range 31-82) with an acute myocardial infarction (MI) suitable for thrombolytic therapy were included in this study. Autoantibodies against oxidized low-density lipoprotein (LDL) were determined by enzyme-linked immunosorbent assay (ELISA). Patients (n = 10) with marked elevation of the MB isoenzyme of creatinine kinase (CK-MB)-mass had significant decreases of oLDL-Ab during the acute phase, with a minimum after 8 h following the onset of thrombolytic therapy (within-group significance: p < .001; between groups: p = .01). Patients (n = 5) with CK-MB-mass values less than 70 ng/ml did not show this phenomenon. Furthermore, significant correlations existed between CK-MB-mass and oLDL-Ab after 6 and 8 h (n = 15; r = .72; p = .003) and the time of the highest CK-MB-mass values (after 12 h) and the time of the maximal decrease of oLDL-Ab (after 8 h) (r = .74; p = .003). Our observations provide further evidence for the release of free radicals and for increased lipid peroxidation during reperfusion after prolonged ischemia. The decrease of oLDL-Ab appears to be a marker for the severity of MI.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Aged, 80 and over -
- Autoantibodies - blood
- Creatine Kinase - blood
- Female -
- Humans -
- Isoenzymes -
- Kinetics -
- Lipoproteins, LDL - immunology
- Male -
- Middle Aged -
- Myocardial Infarction - enzymology
- Myocardial Infarction - immunology
- Oxidation-Reduction -
- Find related publications in this database (Keywords)
- Oxidized LDL Autoantibodies
- Acute Myocardial Infarction
- Free Radicals