Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Malle, E; Schwengerer, E; Paltauf, F; Hermetter, A.
Transfer of pyrene-labelled diacyl-, alkylacyl-, and alkenylacyl-glycerophospholipids from vesicles to human blood platelets.
BBA, BIOMEMBRANES. 1994; 1189(1): 61-64.
Doi: 10.1016/0005-2736(94)90280-1
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- Führende Autor*innen der Med Uni Graz
- Malle Ernst
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- Abstract:
- The present study was aimed at investigating the spontaneous transfer of fluorescently labelled serine- and choline-glycerophospholipids from unilamellar vesicles to resting human blood platelets. The most effectively transferred phospholipids were pyrene-phosphatidylserine (PS) and the ether analogues of choline-glycerophospholipids, e.g., pyrene-alkylacyl- and pyrene-1'-alkenylacyl-glycerophosphocholines (plasmalogens). Transfer of pyrene-diacyl-glycerophosphocholine and pyrene-phosphatidic acid was almost not detectable under the same experimental conditions. The fast intermembrane PS-transfer could be explained by the very high degree of adsorption of PS donor vesicles to the platelet plasma membrane. The short halftime of transfer rate (12-14 min) and the high incorporation (1.08-2.16% of total platelet glycerophosphocholines) observed for ether choline-phospholipids in contrast to pyrene-PS (20 min, 0.8% of total platelet PS), could be interpreted in terms of their bulk membrane properties.
- Find related publications in this database (using NLM MeSH Indexing)
- Blood Platelets - metabolism
- Humans - metabolism
- Lipid Bilayers - metabolism
- Phosphatidic Acids - metabolism
- Pyrenes - metabolism