Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Zweiker, R; Eber, B; Samonigg, H; Reisinger, EC; Kasparek, A; Schumacher, M; Fruhwald, FM; Apfelbeck, U; Klein, W.
Toxoplasmosis peri-myocarditis as initial manifestation of highly malignant non-Hodgkin's lymphoma
Z Kardiol. 1994; 83(3):234-237
(- Case Report)
Web of Science
PubMed
- Führende Autor*innen der Med Uni Graz
- Zweiker Robert
- Co-Autor*innen der Med Uni Graz
- Apfelbeck Ute
- Fruhwald Friedrich
- Kasparek Anne-Katrin
- Samonigg Hellmut
- Schumacher Martin
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Abstract:
- A case report of a 28-year-old mother of two children with FUO is presented. Physical examination revealed an anemic and febrile woman, who lost 10 kg of weight during the past 3 months. Furthermore, two lymphatic nodes with diameters below 1 cm were detected at the neck and inguinal region. A search for origin of fever including evaluation of foci, malignancies and laboratory investigations was primarily unsuccessful. At day 7 after admission a pericardial murmur could be heard. Echocardiography revealed a pericardial effusion, which increased up to 4 cm during the following days, leading to hemodynamic impairment and asystole. Immediate CR was successful, pericardial effusion was aspirated. Looking for etiology of fever the presence of IgM-antibodies against toxoplasma gondii by an ELISA test was possible. Therefore, toxoplasmosis was diagnosed and a treatment-regimen comprising pyrimethamin and sulfadiazin was initiated. Because of the threat to life and very high titers of C-reactive protein, antibiotic therapy (imipenem) was given additionally. An immunologic impairment was excluded by normal ratio of CD4:CD8 of lymphocytes, normal HIV-test and a nonsuspicious Jamshidi-biopsy of the bone marrow. However, in week 9 after admission lymphatic node-tumors suddenly appeared at the neck and pulmonary hilus. After diagnostic exstirpation a malignant non-Hodgkin-lymphoma (T-cell-type) was diagnosed. It is concluded that in obscure pericardial effusion toxoplasmosis should be considered and that this manifestation may be a precursor of malignant non-Hodgkin-lymphoma.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Biopsy -
- Diagnosis, Differential -
- Diagnostic Imaging -
- Female -
- Humans -
- Lymph Nodes - pathology
- Lymphoma, Large-Cell, Anaplastic - complications
- Lymphoma, T-Cell - complications
- Myocarditis - diagnosis
- Neoplasm Staging - diagnosis
- Opportunistic Infections - diagnosis
- Pericarditis - diagnosis
- Toxoplasmosis - diagnosis
- Find related publications in this database (Keywords)
- Fever of Unknown Origin
- Toxoplasmosis
- Pericarditis
- Pericardial Effusion
- Myocarditis
- Malignant Non-Hodgkin-Lymphoma