Medizinische Universität Graz - Research portal
Selected Publication:
Wolf, P; Rieger, E; Kerl, H.
Topical photodynamic therapy with endogenous porphyrins after application of 5-aminolevulinic acid. An alternative treatment modality for solar keratoses, superficial squamous cell carcinomas, and basal cell carcinomas?
J Am Acad Dermatol. 1993; 28(1):17-21
Doi: 10.1016/0190-9622(93)70002-B
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- Leading authors Med Uni Graz
- Kerl Helmut
- Wolf Peter
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- Abstract:
- BACKGROUND: Topical photodynamic therapy with endogenous porphyrins consists of irradiation of a tumor with visible light after the application of exogenous 5-aminolevulinic acid. OBJECTIVE: To assess the effectiveness of this modality, patients with precancerous conditions and various skin cancers were treated. METHODS: Thirteen patients with 70 skin lesions were enrolled. Standard treatment involved the topical application of 20% 5-aminolevulinic acid in an oil-in-water emulsion. The emulsion was applied under an occlusive dressing for 4 to 8 hours before exposure to photoactivating light. RESULTS: We observed a complete response after a single treatment for all 9 solar keratoses, 5 of 6 early invasive squamous cell carcinomas, and 36 of 37 superficial basal cell carcinomas. Only 1 of 10 nodulo-ulcerative basal cell carcinomas completely resolved. Eight cutaneous metastases of malignant melanoma were therapeutic failures. CONCLUSION: Topical photodynamic therapy with endogenous porphyrins is effective for superficial epithelial skin tumors.
- Find related publications in this database (using NLM MeSH Indexing)
- Administration, Cutaneous -
- Adult -
- Aged -
- Aged, 80 and over -
- Aminolevulinic Acid - administration and dosage
- Carcinoma, Basal Cell - drug therapy
- Carcinoma, Squamous Cell - drug therapy
- Female - drug therapy
- Follow-Up Studies - drug therapy
- Humans - drug therapy
- Keratosis - drug therapy
- Male - drug therapy
- Middle Aged - drug therapy
- Photochemotherapy - methods
- Porphyrins - biosynthesis
- Skin Neoplasms - drug therapy