Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Leithner, A; Gapp, M; Radl, R; Pascher, A; Krippl, P; Leithner, K; Windhager, R; Beham, A.
Immunohistochemical analysis of desmoid tumours.
J CLIN PATHOL. 2005; 58(11): 1152-1156.
Doi: 10.1136/jcp.2005.026278
[OPEN ACCESS]
Web of Science
PubMed
FullText
FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Leithner Andreas
- Co-Autor*innen der Med Uni Graz
- Beham Alfred
- Krippl Peter
- Leithner Katharina
- Pascher Arnulf
- Radl Roman
- Windhager Reinhard
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- Background/AIMS: Although the standard treatment for desmoid tumours is complete surgical resection with wide margins, the optimal adjuvant treatment for recurrent or inoperable disease is unclear, often being based on sporadic immunohistochemical reports with a low number of cases. Therefore, a large immunohistochemical study was performed, to provide a theoretical basis for adjuvant treatment regimens.METHODS: One hundred and sixteen tissue samples from 80 patients (49 female, 31 male; mean age, 34 years; range, 0-83) with desmoid tumours (46 extra-abdominal, 21 abdominal, 13 intra-abdominal) were tested for oestrogen receptors alpha and beta, progesterone and androgen receptors, and somatostatin, in addition to HER2, cathepsin D, Ki-67, and c-KIT by immunohistochemistry.RESULTS: All samples were negative for oestrogen receptor alpha, HER2, and the progesterone receptor. Positive staining for the androgen receptor was found in six extra-abdominal cases. Staining for oestrogen receptor beta was positive in four extra-abdominal, two abdominal, and one intra-abdominal case. Staining for somatostatin was positive in six extra-abdominal, two abdominal, and one intra-abdominal case, and staining for cathepsin D was positive in all cases. Positive staining for Ki-67 was found in 14 extra-abdominal, three abdominal, and three intra-abdominal cases. C-KIT was detectable in one abdominal case only.CONCLUSIONS: The data from this immunohistochemical study show that the published effects of antioestrogens and imatinib mesylate in the treatment of aggressive fibromatoses may not be attributable to oestrogen receptor alpha or c-KIT expression.
- Find related publications in this database (using NLM MeSH Indexing)
- Abdominal Neoplasms - chemistry
- Adolescent - chemistry
- Adult - chemistry
- Aged - chemistry
- Aged, 80 and over - chemistry
- Cathepsin D - analysis
- Chemotherapy, Adjuvant - analysis
- Child - analysis
- Child, Preschool - analysis
- Female - analysis
- Fibromatosis, Aggressive - drug therapy
- Humans - drug therapy
- Infant - drug therapy
- Infant, Newborn - drug therapy
- Ki-67 Antigen - analysis
- Male - analysis
- Middle Aged - analysis
- Neoplasm Proteins - analysis
- Proto-Oncogene Proteins c-kit - analysis
- Receptors, Androgen - analysis
- Receptors, Estrogen - analysis
- Receptors, Progesterone - analysis
- Soft Tissue Neoplasms - chemistry
- Somatostatin - analysis
- Tumor Markers, Biological - analysis