Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Weger, M; Renner, W; Steinbrugger, I; Cichocki, L; Temmel, W; Stanger, O; El-Shabrawi, Y; Lechner, H; Schmut, O; Haas, A.
Role of thrombophilic gene polymorphisms in branch retinal vein occlusion.
OPHTHALMOLOGY. 2005; 112(11): 1910-1915.
Doi: 10.1016/j.ophtha.2005.05.019
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PubMed
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- Führende Autor*innen der Med Uni Graz
- Weger Martin
- Co-Autor*innen der Med Uni Graz
- El-Shabrawi Yosuf
- Haas Anton
- Renner Wilfried
- Schmut Otto
- Steinbrugger Iris
- Temmel Werner
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- Abstract:
- OBJECTIVE: Branch retinal vein occlusion (BRVO) is a common cause of severe visual loss. Numerous risk factors, including arterial hypertension, diabetes mellitus, and arteriosclerosis, have been identified. Gene polymorphisms affecting hemostasis may also play a role in the pathogenesis of BRVO. The present study was therefore done to determine the prevalence of genetic polymorphisms in factors implicated in hypercoagulability among patients with BRVO. DESIGN: Retrospective case-control study. PARTICIPANTS: The study cohort consisted of 294 patients with BRVO and 294 control subjects, matched for age and gender. METHODS: Determination of genotypes was done by allele-specific digestion of polymerase chain reaction products, or by 5' exonuclease assay (TaqMan). MAIN OUTCOME PARAMETERS: Genotypes of factor V R506Q (factor V Leiden), prothrombin 20210G>A, fibrinogen beta -455G> A, factor XII (FXII) 46C>T, and ITGA2 807C>T (platelet glycoprotein Ia [GPIa] 807C>T) and ITGB3 L59P (platelet GPIIIa PlA1/PlA2) polymorphisms. RESULTS: Genotype distributions of the investigated gene polymorphisms did not differ significantly between patients and control subjects. In contrast, significantly increased prevalences of arterial hypertension and hypercholesterolemia were found among patients with BRVO. In a logistic regression analysis, the presence of arterial hypertension was associated with an odds ratio (OR) of 2.32 (95% confidence interval [CI], 1.62-3.32), whereas hypercholesterolemia yielded an OR of 2.54 (95% CI, 1.74-3.70) for BRVO. CONCLUSION: Our data indicate that the prevalences of the investigated gene polymorphisms do not differ significantly in patients with BRVO and control subjects. This suggests that these polymorphisms are not major risk factors for BRVO.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Aged, 80 and over -
- Case-Control Studies -
- Factor V - genetics
- Factor XII - genetics
- Female - genetics
- Fibrinogen - genetics
- Genotype - genetics
- Humans - genetics
- Hypercholesterolemia - genetics
- Hypertension - genetics
- Integrin alpha2 - genetics
- Integrin beta3 - genetics
- Male - genetics
- Middle Aged - genetics
- Polymerase Chain Reaction - genetics
- Polymorphism, Genetic - physiology
- Prevalence - physiology
- Prothrombin - genetics
- Retinal Vein Occlusion - genetics
- Retrospective Studies - genetics
- Risk Factors - genetics
- Thrombophilia - genetics