Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Deutschmann, A; Mache, CJ; Bodo, K; Zebedin, D; Ring, E.
Successful treatment of chronic recurrent multifocal osteomyelitis with tumor necrosis factor-alpha blockage.
PEDIATRICS. 2005; 116(5): 1231-1233.
Doi: 10.1542/peds.2004-2206
(- Case Report)
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- Führende Autor*innen der Med Uni Graz
- Deutschmann Andrea
- Co-Autor*innen der Med Uni Graz
- Bodo Koppány Bonifác
- Mache Christoph
- Ring Ekkehard
- Zebedin Doris
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- Abstract:
- We describe the case of an 18-year-old girl with chronic recurrent multifocal osteomyelitis (CRMO) over a period of 10 years. She had suffered predominantly from very painful recurrent swelling of her cheeks. Various therapeutic regimens including nonsteroidal antiinflammatory drugs and steroids had shown only a partial or temporary response. Because tumor necrosis factor-alpha-blocking agents have been successfully applied in Crohn's-associated CRMO and the related SAPHO (synovitis, acne, pustulosis, hyperostosis, and osteitis) syndrome, tumor necrosis factor-alpha-blocking therapy with infliximab was initiated. Thereafter, apart from 1 mild episode, no additional recurrences were observed during 21 months of follow-up. Infliximab was well tolerated, and steroids were tapered off. Our observation indicates that infliximab may be an effective therapeutic option in CRMO.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Antibodies, Monoclonal - therapeutic use
- Biopsy -
- Chronic Disease -
- Female -
- Humans -
- Osteomyelitis - diagnosis Osteomyelitis - drug therapy Osteomyelitis - pathology
- Recurrence -
- Skull - pathology
- Tumor Necrosis Factor-alpha - antagonists and inhibitors