Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Meinitzer, A; Zink, M; März, W; Baumgartner, A; Halwachs-Baumann, G.
Midazolam and its metabolites in brain death diagnosis.
INT J CLIN PHARM THERAPEUTICS. 2005; 43(11): 517-526.
Doi: 10.5414/CPP43517
Web of Science
PubMed
FullText
FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Baumann Gabriele
- Meinitzer Andreas
- Co-Autor*innen der Med Uni Graz
- Baumgartner Anton
- März Winfried
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- OBJECTIVE: There is only limited knowledge on the pharmacokinetics of midazolam and its active metabolites in potential organ donors. Before establishing the diagnosis of brain death, drugs interfering with the neurological assessment have to be washed out. National guidelines advise a waiting time of 12 hours. The aim of our study was to evaluate whether it is sufficient to rely on a calculated waiting time. METHODS: As examples of typical pharmacokinetics of midazolam and its metabolites, we followed the concentration over time in four potential organ donors with immunoassays and high-performance liquid chromatography (HPLC). RESULTS AND CONCLUSIONS: In each of the 4 patients studied, the elimination of midazolam and/or midazolam metabolites was delayed. As long as brain death diagnosis requires that drugs interfering with the clinical assessment must be at levels below the therapeutic range, monitoring of midazolam and metabolites appears mandatory.
- Find related publications in this database (using NLM MeSH Indexing)
- Adjuvants, Anesthesia - blood Adjuvants, Anesthesia - pharmacokinetics
- Adult -
- Anesthetics, Intravenous - blood Anesthetics, Intravenous - pharmacokinetics
- Brain Death - diagnosis
- Chromatography, High Pressure Liquid -
- Glucuronides - blood
- Humans -
- Hypnotics and Sedatives - blood Hypnotics and Sedatives - pharmacokinetics
- Midazolam - analogs and derivatives Midazolam - blood Midazolam - pharmacokinetics
- Middle Aged -
- Tissue Donors -
- Find related publications in this database (Keywords)
- midazolam
- pharmacokinetics
- brain death diagnosis