Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Wegscheider, BJ; Weger, M; Renner, W; Posch, U; Ulrich, S; Hermann, J; Ardjomand, N; Haller-Schober, EM; El-Shabrawi, Y.
Role of the CCL2/MCP-1 -2518A>G gene polymorphism in HLA-B27 associated uveitis.
MOL VIS. 2005; 11(9-10): 896-900.
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Web of Science
PubMed
- Leading authors Med Uni Graz
- El-Shabrawi Yosuf
- Langner-Wegscheider Beate Julia
- Co-authors Med Uni Graz
- Ardjomand Navid
- Haller-Schober Eva-Maria
- Hermann Josef
- Posch Ursula
- Renner Wilfried
- Ulrich Silvia
- Weger Martin
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- Abstract:
- PURPOSE: Acute anterior uveitis (AAU) is the most common form of uveitis. Up to 50% of patients with AAU are HLA-B27 positive. Since HLA B27 itself plays only a minor role in the overall genetic background, other genetic variants are likely to contribute to the susceptibility to AAU. The chemokine (C-C motif) ligand 2 (CCL2) gene, coding for monocyte chemoattractant protein-1 (MCP-1), a chemotactic cytokine, is involved in the induction of uveitis. A CCL2 gene polymorphism, which is characterized by an A>G substitution at nucleotide -2518 in the promoter region of CCL2 has been previously shown to affect MCP-1 synthesis. The purpose of the present study was to investigate a hypothesized association between this genetic variant and the presence of HLA-B27 associated AAU. METHODS: The study group comprised 114 patients with HLA-B27 associated AAU. One hundred and eleven healthy HLA-B27 positive individuals served as the HLA-B27 positive control group, whereas 81 healthy HLA-B27 negative individuals served as a HLA-B27 negative control group. Genotyping for the CCL2 -2518A>G polymorphism was performed by polymerase chain reaction. RESULTS: Carriers of a CCL2 -2518G allele were found significantly more often in patients with HLA-B27 associated AAU than among HLA-B27 positive controls (49.2% and 31.5%, respectively; odds ratio 2.1; 95% confidence interval 1.2-3.6; p=0.007). CONCLUSIONS: Our data suggest that the CCL2 -2518A>G polymorphism may play a role in HLA-B27 associated acute anterior uveitis.
- Find related publications in this database (using NLM MeSH Indexing)
- Acute Disease -
- Adult -
- Case-Control Studies -
- Chemokine CCL2 - genetics
- Female - genetics
- Genotype - genetics
- HLA-B27 Antigen - genetics
- Humans - genetics
- Male - genetics
- Middle Aged - genetics
- Polymerase Chain Reaction - genetics
- Polymorphism, Single Nucleotide - physiology
- Retrospective Studies - physiology
- Uveitis, Anterior - genetics