Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Haas, A; Walzl, M; Jesenik, F; Walzl, B; Berghold, A; Berglöff, J; Feigl, B; Faulborn, J.
Application of HELP in nonarteritic anterior ischemic optic neuropathy: a prospective, randomized, controlled study.
Graefes Arch Clin Exp Ophthalmol. 1997; 235(1):14-19
Doi: 10.1007%2FBF01007832
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- Führende Autor*innen der Med Uni Graz
- Haas Anton
- Co-Autor*innen der Med Uni Graz
- Berghold Andrea
- Bergloeff Jutta
- Feigl Beatrix
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- Abstract:
- BACKGROUND: Heparin-induced extracorporeal LDL/fibrinogen precipitation (HELP) eliminates selectively fibrinogen, LDL, cholesterol, triglycerides and LP(a) from blood plasma using extracorporeal circulation. The reduction of fibrinogen and LDL by about 50% after only one procedure immediately improves the hemorheological situation. METHOD: In a prospective, randomized, controlled study over a period of 3 months, 40 patients with nonarteritic ischemic optic neuropathy (NAION) were randomly assigned to either HELP or hemodilution therapy to determine the efficacy of these two treatments on visual acuity and fields. RESULTS: After transformation of the Snellen acuity into logMAR units the statistical analysis did not show a significant difference between the two groups (P = 0.48). An increase of the visual acuity by two or more lines was obtained in 9 patients (47.4%) of the HELP group, 10 (52.6%) remained stable and none got worse. In the hemodilution group, visual acuity increased in patients (33.4%), 9 (42.8%) remained stable and 5 (23.8%) experienced a decrease. The calculated mean sensitivity of visual fields at baseline improved statistically significantly (P < 0.01) in the HELP group from 6.83 +/- 4.52 dB to 8.27 +/- 4.89 dB, but did not change significantly in the hemodilution group (6.25 +/- 4.12 dB to 6.12 +/- 3.92 dB). CONCLUSION: The HELP system seems to be safe and more effective than hemodilution in improving the hemorheological and the functional situation in NAION and could be a promising regimen in the treatment of NAION.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Arteritis - blood
- Blood Viscosity - blood
- Evoked Potentials, Visual - physiology
- Extracorporeal Circulation - physiology
- Female - physiology
- Fibrinogen - metabolism
- Fibrinolytic Agents - administration and dosage
- Fractional Precipitation - administration and dosage
- Hemodilution - methods
- Heparin - administration and dosage
- Humans - administration and dosage
- Lipoproteins, LDL - blood
- Male - blood
- Middle Aged - blood
- Optic Neuropathy, Ischemic - blood
- Prospective Studies - blood
- Visual Acuity - blood
- Visual Fields - blood