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Aglas, F; Fruhwald, FM; Chlud, K.
Results of efficacy study with diclofenac/orphenadrine infusions in patients with musculoskeletal diseases and functional disorders
Acta Med Austriaca. 1998; 25(3):86-90
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Co-authors Med Uni Graz: Fruhwald Friedrich
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Abstract:: During a post-marketing surveillance study, 641 patients (age range 18 to 86 years) with painful rheumatic diseases, mostly of vertebral etiology, were given ready-for-use infusions containing a combination of the non-steroid antiphlogistic agent diclofenac (75 mg) and the muscle relaxing agent orphenadrine (30 mg) parenterally for 7 days. The goal of the study was to investigate efficacy, tolerability, and acceptance of this intravenous therapy in wide use in physicians' practices. At the end of treatment, the global evaluation resulted in a score of 1.6 on a scale of 1 (very good) to 4 (insufficient). The tolerability score was 1.3 and the acceptability score was 1.5. Only 20 patients (3.1%) had adverse effects, most of which were of gastrointestinal nature. The medication proved appropriate for use in the treatment of painful spine syndromes, inflammatory osteoarthritis, painful osteoporosis, post-operative conditions, and extra-articular rheumatism and could represent a first step towards multi-factorial therapeutic management of these diseases.
Find related publications in this database (using NLM MeSH Indexing): Adolescent -; Adult -; Aged -; Aged, 80 and over -; Anti-Inflammatory Agents, Non-Steroidal - administration and dosage; Diclofenac - administration and dosage; Dose-Response Relationship, Drug - administration and dosage; Drug Administration Schedule - administration and dosage; Drug Therapy, Combination - administration and dosage; Female - administration and dosage; Humans - administration and dosage; Infusions, Intravenous - administration and dosage; Male - administration and dosage; Middle Aged - administration and dosage; Muscle Relaxants, Central - administration and dosage; Orphenadrine - administration and dosage; Pain Measurement - administration and dosage; Practice Guidelines - administration and dosage; Product Surveillance, Postmarketing - administration and dosage; Rheumatic Diseases - drug therapy
Find related publications in this database (Keywords): Diclofenac; Orphenadrine; Musculoskeletal Syndromes; Back Pain; Infusion Therapy