Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Zechner, R; Strauss, J; Frank, S; Wagner, E; Hofmann, W; Kratky, D; Hiden, M; Levak-Frank, S.
The role of lipoprotein lipase in adipose tissue development and metabolism.
Int J Obes Relat Metab Disord. 2000; 24 Suppl 4:S53-S56
Doi: 10.1038/sj.ijo.0801506
[OPEN ACCESS]
Web of Science
PubMed
FullText
FullText_MUG
- Co-Autor*innen der Med Uni Graz
- Frank Sasa
- Kratky Dagmar
- Levak Sanja
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- Lipoprotein lipase (LPL) is essential for the hydrolysis and distribution of triglyceride-rich lipoprotein-associated fatty acids among extrahepatic tissues. Additionally, the enzyme facilitates several non-lipolysis associated functions including the cellular uptake of whole lipoprotein particles and lipophilic vitamins. The tissue-specific variations of LPL expression have been implicated in the pathogenesis of various lipid disorders, obesity and atherosclerosis. Transgenic technology provided the means to study the physiological response to the overexpression or absence of the enzyme in adipose tissue, muscle and macrophages. The effects of varying LPL expression in adipose tissue and muscle are summarized in this article.
- Find related publications in this database (using NLM MeSH Indexing)
- Adipose Tissue - growth and development
- Animals - growth and development
- Gene Expression Regulation - growth and development
- Humans - growth and development
- Lipoprotein Lipase - genetics
- Mice - genetics
- Mice, Transgenic - genetics
- Find related publications in this database (Keywords)
- lipoprotein lipase
- adipose tissue
- muscle
- transgenic mouse