Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Archelos, JJ; Previtali, SC; Hartung, HP.
The role of integrins in immune-mediated diseases of the nervous system.
Trends Neurosci. 1999; 22(1):30-38
Doi: 10.1016%2FS0166-2236%2898%2901287-9
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- Führende Autor*innen der Med Uni Graz
- Archelos-Garcia Juan-Jose
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- Abstract:
- Immune-mediated diseases of the CNS and PNS, such as multiple sclerosis and Guillain-Barré syndrome, respectively, constitute a major cause of transient and permanent neurological disability in the adult.The aetiology and pathogenesis of these disorders are only partially understood. On a cellular level, focal mononuclear-cell infiltration with demyelination and eventual axonal loss is a crucial pathogenetic event that leads to inflammation and subsequent dysfunction. Here, the evidence that integrins, a family of cell adhesion molecules, expressed on neural and immune cells might play a central role in immune cell recruitment to the CNS and PNS, and probably in tissue repair is reviewed. Distinct integrin expression patterns are observed in multiple sclerosis and Guillain-Barré syndrome. Therapeutic targeting of integrins has been very successful in the corresponding animal models and holds promise as a novel treatment strategy to combat human immune-mediated disorders of the nervous system.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Autoimmune Diseases - physiopathology
- Humans - physiopathology
- Immune System Diseases - physiopathology
- Integrins - physiology
- Multiple Sclerosis - physiopathology
- Nervous System Diseases - physiopathology
- Neuritis - physiopathology
- Polyradiculoneuropathy - physiopathology