Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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Gewählte Publikation:

Heinemann, A; Stauber, RE.
The role of inducible nitric oxide synthase in vascular hyporeactivity of endotoxin-treated and portal hypertensive rats.
EUR J PHARMACOL. 1995; 278(1): 87-90. Doi: 10.1016%2F0014-2999%2895%2900138-B
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Führende Autor*innen der Med Uni Graz: Heinemann Akos
Co-Autor*innen der Med Uni Graz: Stauber Rudolf
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Abstract:: The involvement of the inducible nitric oxide (NO) synthase in the vascular hyporeactivity in portal vein-ligated rats was assessed in isolated perfused mesenteric arterial beds. Aminoguanidine, a selective inhibitor of the inducible NO synthase, restored the pressor responses to methoxamine in arteries of endotoxin-treated rats, but was ineffective in hyporeactive portal vein-ligated vessels. NG-Nitro-L-arginine methyl ester enhanced the responsiveness both in portal vein-ligated and sham-operated rats, without changing the difference between the two groups. These results not only indicate that the inducible NO synthase is not involved in the hyporeactivity to methoxamine in mesenteric arteries of portal hypertensive rats, but also suggest a role for factors other than NO.
Find related publications in this database (using NLM MeSH Indexing): Amino Acid Oxidoreductases - antagonists and inhibitors; Animals - antagonists and inhibitors; Arginine - analogs and derivatives; Disease Models, Animal - analogs and derivatives; Endotoxins - toxicity; Enzyme Induction - drug effects; Escherichia coli - metabolism; Guanidines - pharmacology; Hypertension, Portal - metabolism; Male - metabolism; Mesenteric Arteries - metabolism; Methoxamine - toxicity; NG-Nitroarginine Methyl Ester - toxicity; Nitric Oxide - antagonists and inhibitors; Nitric Oxide Synthase - antagonists and inhibitors; Rats - antagonists and inhibitors; Rats, Sprague-Dawley - antagonists and inhibitors; Vascular Resistance - physiology
Find related publications in this database (Keywords): Acetylcholine; Aminoguanidine; Lipopolysaccharide; Mesenteric Arterial Bed; N-G-Nitro-L-Arginine Methyl Ester; Portal Vein Ligation; (Portal Hypertensive Rat)