Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Hermetter, A; Sommer, A; Gorges, R; Prenner, E; Kostner, GM; Paltauf, F.
Apoprotein-phospholipid interactions in Lp(a).
Chem Phys Lipids. 1994; 67-68(1):115-119
Doi: 10.1016/0009-3084(94)90130-9
Web of Science
PubMed
FullText
FullText_MUG
- Co-Autor*innen der Med Uni Graz
- Kostner Gerhard
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- Lipoprotein (a) (Lp(a)) and low-density lipoprotein (LDL) are structurally related to each other. Both exhibit identical phospholipid compositions and possess one molecule of apoprotein B-100 (apoB). Lp(a) contains, in addition, apoprotein (a) (apo(a)), which localizes to the particle surface and interacts with the apoB component by non-covalent and covalent forces. Protein-protein interaction is probably interrelated with protein-lipid interaction. Fluorescent analogs of phosphatidylcholine and sphingomyelin were inserted into the surface layer of LDL and Lp(a). The obtained fluorescence data reflecting mobility and distributional heterogeneity of the labeled lipids provided evidence that apo-proteins discriminate between choline phospholipids and preferentially associate with phosphatidylcholine. This effect is enhanced in Lp(a) because of the presence of apolipoprotein (a). Higher affinity for Lp(a) as compared with LDL was also observed with a fluorescent diether analog of phosphatidylcholine in native serum. In contrast, the time-dependent transfer of the same lipid into Lp(a) was slower compared with LDL, probably as a consequence of the more rigid surface of the former lipoprotein.
- Find related publications in this database (using NLM MeSH Indexing)
- Apolipoproteins - chemistry
- Apoprotein(a) - chemistry
- Fluorescence Polarization - chemistry
- Fluorescent Dyes - chemistry
- Humans - chemistry
- Lipoprotein(a) - chemistry
- Lipoproteins, LDL - chemistry
- Molecular Structure - chemistry
- Phosphatidylcholines - chemistry
- Phospholipids - chemistry
- Protein Binding - chemistry
- Sphingomyelins - chemistry
- Find related publications in this database (Keywords)
- Lipoprotein Structure
- Fluorescent Phospholipids
- Pyrene Diether Phosphatidylcholine
- Diphenylhexatriene Phospholipid