Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Liebmann, PM; Wölfler, A; Schauenstein, K.
Interaction of the epiphysis and the immune system
Wien Klin Wochenschr. 1997; 109(18):730-736
Web of Science
PubMed
- Führende Autor*innen der Med Uni Graz
- Liebmann-Holzmann Peter
- Co-Autor*innen der Med Uni Graz
- Schauenstein Konrad
- Wölfler Albert
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Abstract:
- First indications that the pineal gland may be involved in endocrine immunomodulation came from early reports on anti-tumor effects of pineal extracts in animals and humans. In the meantime, evidence has accumulated suggesting that melatonin, the major endocrine product of the pineal gland-as a well preserved molecule during evolution-is indeed involved in the feedback between neuroendocrine and immune functions. At present we are beginning to understand the mechanisms of action by which melatonin affects cellular functions, and from the variety of possible direct and indirect interactions it appears that melatonin may play a complex physiological role in neuroimmunomodulation. In this article we present a critical review of the numerous reports on the influence of melatonin on immune functions and discuss the possible underlying molecular pathways. In addition, a short comment is given on the current public discussion as to the clinical value of melatonin.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Epiphyses - physiology
- Humans - physiology
- Immunity, Cellular - physiology
- Immunocompetence - physiology
- Melatonin - physiology
- Neuroimmunomodulation - physiology
- Find related publications in this database (Keywords)
- Melatonin
- Immune Functions
- Melatonin Receptors
- Extrapineal Synthesis
- Lymphatic System
- Physiological Role
- Neuroimmunomodulation
- Psychoneuroimmunology