Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Kieseier, BC; Archelos, JJ; Storch, M; Gold, R; Hartung, HP.
The immunopathogenesis of multiple sclerosis. A survey of recent advances and implications for future therapy.
Wien Klin Wochenschr. 1999; 111(17):728-737
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- Co-Autor*innen der Med Uni Graz
- Archelos-Garcia Juan-Jose
- Storch Maria
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- Abstract:
- The etiology of multiple sclerosis (MS) still remains elusive. However, the association of the disease with relevant genes, the characteristic white matter infiltrates, similarities with animal models, and the fact that MS can be treated with immunomodulatory and immunosuppressive therapies support the notion that this disorder is autoimmune in nature. During the last few years the knowledge about the mechanisms involved in the pathogenesis of MS increased rapidly. In this review, recent advances in our understanding about relevant pathomechanisms in inflammatory demyelinating diseases of the central nervous system will be discussed and the rational of some novel immunotherapies is explained in context of the current understanding of immunological principles.
- Find related publications in this database (using NLM MeSH Indexing)
- Autoimmunity -
- Cytokines - immunology
- Humans - immunology
- Immune Tolerance - immunology
- Immunotherapy - methods
- Multiple Sclerosis - immunology
- T-Lymphocytes - immunology
- Vaccines - immunology
- Find related publications in this database (Keywords)
- Multiple Sclerosis
- Demyelination
- Autoimmunity
- Axonal Loss
- Immunotherapy