Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Wilders-Truschnig, MM; Warnkross, H; Leb, G; Langsteger, W; Eber, O; Tiran, A; Dobnig, H; Passath, A; Lanzer, G; Drexhage, HA.
The effect of treatment with levothyroxine or iodine on thyroid size and thyroid growth stimulating immunoglobulins in endemic goitre patients.
Clin Endocrinol (Oxf). 1993; 39(3):281-286
Doi: 10.1111/j.1365-2265.1993.tb02367.x
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- Führende Autor*innen der Med Uni Graz
- Truschnig-Wilders Martini
- Co-Autor*innen der Med Uni Graz
- Dobnig Harald
- Lanzer Gerhard
- Tiran Andreas
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- Abstract:
- OBJECTIVE We assessed the effect of levothyroxine or iodine on thyroid size and on thyroid growth stimulating immunoglobulins in endemic goitre patients. DESIGN Levothyroxine or iodine was given orally in an open randomized prospective study (100 and 200 mug respectively). PATIENTS Thirty-seven euthyroid patients with diffuse iodine deficiency goitres and thyroid growth stimulating immunoglobulins were studied. MEASUREMENTS Thyroid size, thyroid growth stimulating immunoglobulins (mitosis arrest assay), basal TSH, free T3, free T4, thyroid anti-microsomal antibodies, antithyroglobulin antibodies, anti-TSH receptor antibodies and urinary iodine excretion were measured. RESULTS Thyroid size decreased significantly in both groups, in the levothyroxine group more than in the iodine treated group. Thyroid growth stimulating immunoglobulins levels also decreased significantly in both groups. Between groups there was no statistically significant difference. A statistically significant correlation between thyroid growth stimulating immunoglobulins reduction profiles and goitre size reduction could not be established. TSH levels became suppressed in the levothyroxine group while the T4 values rose; in the iodine treated group TSH levels stayed constant as did T4. None of the patients developed thyroid microsomal or thyroglobulin autoantibodies and/or hyperthyroidism during the treatment. CONCLUSIONS Levothyroxine as well as iodine was effective in reducing thyroid size as well asthyroid growth stimulating immunoglobulins levels in endemic goitre patients. Since in both groups TSH levels were not related to thyroid size reduction, other factors than TSH suppression must be responsible for the observed thyroid size reduction. Iodine itself by virtue of its antiproliferative action on thyrocytes may have had a direct action on the goitre reduction during iodine treatment; however, the levothyroxine dose, containing less iodine, had a similar effect. A complicated picture hence emerges with regard to factors involved in the shrinkage of iodine deficiency goitre during thyroxine or iodine therapy. These findings indicate that TSH and thyroid growth promoting immunoglobulins are not the only influences on the size of endemic goitres, although it cannot be excluded that these two factors contribute to influence the pathogenetic process.
- Find related publications in this database (using NLM MeSH Indexing)
- Antibodies - immunology
- Autoantibodies - analysis
- Female -
- Goiter, Endemic - blood
- Humans -
- Immunoglobulins, Thyroid-Stimulating -
- Iodine - therapeutic use
- Male -
- Prospective Studies -
- Thyroid Gland - drug effects
- Thyroid Hormones - blood
- Thyroxine - therapeutic use