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Schöll, W; Konstantiniuk, P; Kern, I; Giuliani, A.
The Effect of Duration of Labor on the Immunological Status of Fetuses
GEBURTSH FRAUENHEILK 1996 56: 634-639. Doi: 10.1055/s-2007-1022298
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Leading authors Med Uni Graz: Schöll Wolfgang
Co-authors Med Uni Graz: Giuliani Albrecht; Konstantiniuk Peter
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Abstract:: Lymphocyte subpopulations and the differential blood count in umbilical cord blood yield information on the immunological status of fetuses. Is there a difference in the immunological status with increasing duration of labour after normal spontaneous deliveries? Study design: In a prospective non-randomised study the immunological status of 120 full term healthy neonates of mothers with uneventful pregnancies and spontaneous deliveries was determined in umbilical cord blood by flow cytometry after labelling lymphocytes with either PE or FITC conjugated monoclonal antibodies. 60 deliveries with duration of labour shorter than the median value were compared to 60 exceeding this period. Data were analysed via either the Student T test or the Mann-Whitney Wilcoxon U test on SPSS software. Results: The median value of the duration of labour of all 120 deliveries was 6:20 hours (median = 7:05, std = 2.46). The first group had a median duration of labour of 5:25 hours against a median of 8:10 hours of the second group. Significant elevations of total leukocyte count (16.40 x 10(9)L vs 14.75 x 10(9)/L), total lymphocyte count (5.93 x 10(9)/L vs 5.46 x 10(9)/L), T-suppressor cells (2.26 x 10(9)L vs 1.72 x 10(9)/L), cytotoxic T-cells (0.083 x 10(9)/L vs 0.05 x 10(9)/L) and total natural killer cells (1.51 x 10(9)/L vs 0.97 x 10(9)/L) were observed with prolonged labour. Total T cells (61.50% vs 66.50%), T helper/inducer cells (42.91% vs 49.45%) and the helper/suppressor ratio (1.20 vs 1.50) were significantly lower after prolonged duration of labour. No differences between the two groups were observed for neutrophiles, monocytes, total B cells, activated T (CD3+/HLADR+) cells, T &/or NK (CD57+/ CD8-) cells, (CD57+/CD8+) cells, (CD4+/Leu8-) cells, (CD4+/ Leu8+) cells and DR+ Non-T (CD3-/HLADR+) cells. Conclusions: Prolonged labour influences immunological competent cells of the fetus with stimulation of unspecific immunity and depression of specific cellular immunity.