Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Samsonov, M; Lopatin, J; Tilz, GP; Artner-Dworzak, E; Nassonov, E; Mareev, V; Belenkov, J; Wachter, H; Fuchs, D.
The activated immune system and the renin-angiotensin-aldosterone system in congestive heart failure.
J Intern Med. 1998; 243(2):93-98
Doi: 10.1046%2Fj.1365-2796.1998.00240.x
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- Co-Autor*innen der Med Uni Graz
- Tilz Gernot
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- Abstract:
- OBJECTS: The aim of the study was to investigate a possible relationship between plasma renin activity, angiotensin II, serum levels of angiotensin-converting enzyme, aldosterone and markers of immune activation in congestive heart failure (CHF). PATIENTS AND METHODS: Fifty-three patients (50 male, three female, mean age 46 +/- 16 years) with congestive heart failure were studied. Twenty-eight patients had I or II NYHA class of CHF and 25 patients had III or IV NYHA class (NYHA class, mean +/- SD: 2.3 +/- 0.9). Serum neopterin concentration and hormones were measured by commercial radioimmunoassays. Serum soluble receptors of tumour necrosis factor and interleukin-2 were determined by ELISA. RESULTS: All analytes significantly correlated with NYHA classes (P < 0.05). There existed correlations between neopterin and angiotensin-converting enzyme or aldosterone (rs = 0.35 and rs = 0.36, P < 0.05). The soluble tumour necrosis factor receptor concentrations correlated with plasma renin activity (rs = 0.38, P < 0.05). CONCLUSION: The result of our study suggest that there exists some relationship between the renin-angiotensin-aldosterone system and immune activation in severe congestive heart failure, however, the associations found are rather weak.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aldosterone - blood
- Angiotensin II - blood
- Antigens, CD - blood
- Female - blood
- Heart Failure, Congestive - immunology
- Humans - immunology
- Male - immunology
- Middle Aged - immunology
- Neopterin - blood
- Peptidyl-Dipeptidase A - blood
- Radioimmunoassay - blood
- Receptors, Interleukin-2 - blood
- Receptors, Tumor Necrosis Factor - blood
- Receptors, Tumor Necrosis Factor, Type I - blood
- Renin - blood
- Renin-Angiotensin System - immunology
- Severity of Illness Index - immunology
- Find related publications in this database (Keywords)
- Aldosterone
- Angiotensin
- Congestive Heart Failure
- Immune Activation
- Renin