Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Porta, S; Epple, A; Kvetnansky, R; Leitner, G; Emsenhuber, W; Radkohl, W.
Temporary increase of plasma epinephrine affects stress responses 24 h later.
Physiol Behav. 1995; 58(2):223-228
Doi: 10.1016%2F0031-9384%2895%2900041-G
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PubMed
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- Führende Autor*innen der Med Uni Graz
- Porta Sepp
- Co-Autor*innen der Med Uni Graz
- Leitner Gerhard
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- Abstract:
- The impact of temporary (24 h) implantation of epinephrine tables on catecholamine responses to handling and immobilization 24 h later was investigated in rats. Free plasma epinephrine responded with an increase to both types of stress (77% and 326%, respectively) while controls showed a weaker response to immobilization. The basal level of free plasma norepinephrine was reduced (46% vs. controls) after epinephrine pretreatment, but neither handling nor immobilization had a specific effect on this parameter. In contrast, the basal level of free plasma dopamine was increased after epinephrine pretreatment (183%); however, as with free norepinephrine, there was no specific effect of handling or immobilization. Conjugated plasma epinephrine was significantly lowered after epinephrine pretreatment (44% vs. controls). It did not respond specifically to handling or immobilization except for a stronger response after 20 min of immobilization. Conjugated norepinephrine showed no specific response, but increased nonspecifically after extended immobilization. Conjugated dopamine was lowered (30%-48%) in the E-treated group and did not respond to stress at any time. Thus, a temporary elevation of free plasma epinephrine affected, differentially, basal levels and stress responses of free and conjugated catecholamines 24 h later.
- Find related publications in this database (using NLM MeSH Indexing)
- Adrenergic Agonists - administration and dosage
- Animals - administration and dosage
- Dopamine - blood
- Drug Implants - blood
- Epinephrine - administration and dosage
- Handling (Psychology) - administration and dosage
- Immobilization - administration and dosage
- Male - administration and dosage
- Norepinephrine - blood
- Rats - blood
- Rats, Sprague-Dawley - blood
- Stress, Psychological - blood
- Find related publications in this database (Keywords)
- Epinephrine Implants
- Norepinephrine
- Dopamine
- Plasma Catecholamines
- Conjugated Catecholamines
- Stress Responses of Rats