Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Junger, WG; Hallström, S; Redl, H; Schlag, G.
Inhibition of human, ovine, and baboon neutrophil elastase with Eglin c and secretory leukocyte proteinase inhibitor.
Biol Chem Hoppe Seyler. 1992; 373(3):119-122
Doi: 10.1515/bchm3.1992.373.1.119
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- Co-Autor*innen der Med Uni Graz
- Hallström Seth
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- Abstract:
- The association rate constants (kon) of human, ovine, and baboon neutrophil elastase with two recombinant serine proteinase inhibitors (Eglin c, secretory leukocyte proteinase inhibitor) were compared. The association rate constant of sheep leukocyte elastase (SLE) with Eglin c is about 100 times lower (kon = 2.2 x 10(5) M-1s-1) than that of human elastase (kon = 2.4 x 10(7) M-1s-1). Baboon elastase, however, is as effectively blocked with Eglin c (kon = 2.5 x 10(7) M-1s-1) as human elastase. Secretory leukocyte proteinase inhibitor (SLPI) blocks the elastase of all three species with high efficiency; baboon elastase shows the highest association rate constant (kon = 5.6 x 10(7) M-1s-1) followed by human elastase (kon = 4.1 x 10(7) M-1s-1) and finally sheep elastase (kon = 1.2 x 10(7) M-1s-1). These findings demonstrate marked differences in the inhibition kinetic properties of ovine and human elastase. Concerning a future clinical application of proteinase inhibitors, the baboon seems a more suitable model than sheep to evaluate the effects of Eglin c and SLPI, since both inhibitors block baboon and human elastase with comparable efficiency.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Humans -
- Leukocyte Elastase -
- Pancreatic Elastase - antagonists & inhibitors Pancreatic Elastase - metabolism
- Papio -
- Proteinase Inhibitory Proteins, Secretory -
- Proteins -
- Secretory Leukocyte Peptidase Inhibitor -
- Serine Proteinase Inhibitors - metabolism Serine Proteinase Inhibitors - pharmacology
- Serpins -
- Sheep -
- Find related publications in this database (Keywords)
- HUMAN
- SHEEP
- AND BABOON NEUTROPHIL ELASTASE INHIBITION
- EGLIN-C
- SECRETORY LEUKOCYTE PROTEINASE INHIBITOR