Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Schlag, G; Redl, H; Hallström, S; Radmore, K; Davies, J.
Hyperdynamic sepsis in baboons: I. Aspects of hemodynamics.
Circ Shock. 1991; 34(3):311-318
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- Hallström Seth
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- Abstract:
- The baboon has a number of advantages as a shock model, as its physiological as well as its biochemical behaviour is similar to man. Therefore we have tried to set up a model to mimic the early hyperdynamic phase of clinical sepsis. Seven baboons, 21-25 kg body weight were kept under EEG servocontrolled anesthesia for 8 hr. During this time live E. coli (ATC #33985) 2 x 10(10) BW/8 hr were continuously infused intravenously. Adequate fluid supply with Ringer's solution (up to 40 ml/kg/hr) was given to keep the pulmonary artery wedge pressure at baseline levels; this procedure resulted in a hyperdynamic response with a cardiac output (CO) 20-35% above baseline and a decrease (20-39%) in mean arterial pressure (MAP), leading to a 50% decrease in peripheral resistance. The pulmonary vascular changes were reflected in an increase of the mean pulmonary pressure (PA) to 42% above baseline and a marked rise in pulmonary vascular resistance (PVR) to 50% above baseline with no additional changes in pulmonary gas exchange. After 8 hr both CO and MAP were inversely correlated (r = 0.9-1) with dramatically increased catecholamine plasma levels (15 times above baseline). With continuous infusion of live E. coli (blood levels 10(5)-10(6) CFU/ml) and massive fluid supply we have successfully mimicked hyperdynamic sepsis with severe organ failure after an 8-hr observation period.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Blood Pressure -
- Cardiac Output -
- Colony Count, Microbial -
- Escherichia coli Infections - blood Escherichia coli Infections - microbiology Escherichia coli Infections - physiopathology
- Hemodynamics -
- Leukocyte Count -
- Male -
- Oxygen - blood
- Find related publications in this database (Keywords)
- CLOSED-LOOP ANESTHESIA
- CARDIAC OUTPUT
- TOTAL PERIPHERAL RESISTANCE
- CATECHOLAMINE
- EPINEPHRINE
- NOREPINEPHRINE
- ESCHERICHIA-COLI
- BACTEREMIA
- LEUKOPENIA