Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Rabl, H; Khoschsorur, G; Petek, W.
Antioxidative vitamin treatment: effect on lipid peroxidation and limb swelling after revascularization operations.
World J Surg. 1995; 19(5):738-744
Doi: 10.1007%2FBF00295919
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PubMed
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- Co-Autor*innen der Med Uni Graz
- Khoschsorur Gholamali
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- Abstract:
- The objective of this study was to evaluate the antioxidative properties of the multivitamin cocktail Omnibionta (alpha-tocopherol, ascorbic acid, retinol, vitamin B complex) in terms of diminishing lipid peroxidation with improvement of leg edema performance after limb revascularization operations in humans. Fifty-one subjects were selected; the control group contained 27 patients and the treatment group 24 patients, who received the vitamin cocktail intravenously before the start of reperfusion. All patients suffered from acute or chronic arterial occlusive disease, except two subjects with arterial trauma. MDA-TBARS in plasma, quantified by HPLC, taken as a measure of lipid peroxidation was significantly increased (p < 0.001) in the control group 1 hour after reperfusion onset and decreased to its baseline value within the following 2 hours (0.73 +/- 0.26, 1.21 +/- 0.48, 0.99 +/- 0.48, 0.73 +/- 0.33 nmol/ml). In contrast, in the treatment group MDA-TBARS did not exceed the baseline value during the reperfusion period (0.93 +/- 0.30, 0.70 +/- 0.29, 0.65 +/- 0.23, 0.70 +/- 0.37 nmol/ml). Leg edema, expressed by extremity circumference, was significantly (p < 0.008) elevated in the control group (30.7 +/- 4.04 cm versus 35.35 +/- 4.12 cm) compared to a lack of increase in the treatment group (29.25 +/- 5.13 cm versus 29.76 +/- 5.70 cm). These results suggest that antioxidative vitamin treatment might be valuable in preventing lipid peroxidation and decreasing extremity edema.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Aged, 80 and over -
- Antioxidants - administration and dosage
- Female - administration and dosage
- Humans - administration and dosage
- Ischemia - surgery
- Leg - blood supply
- Lipid Peroxidation - drug effects
- Lymphedema - prevention and control
- Male - prevention and control
- Middle Aged - prevention and control
- Postoperative Complications - prevention and control
- Reactive Oxygen Species - metabolism
- Reperfusion Injury - prevention and control
- Treatment Outcome - prevention and control