Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Vrecko, K; Birkmayer, JG; Krainz, J.
Stimulation of dopamine biosynthesis in cultured PC 12 phaeochromocytoma cells by the coenzyme nicotinamide adeninedinucleotide (NADH).
J NEURAL TRANSM, PARKINSONS. 1993; 5(2): 147-156.
Doi: 10.1007/BF02251205
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- Vrecko Karoline
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- Abstract:
- The activity of the tyrosine hydroxylase, the enzyme which is diminished in the brains of Parkinson patients, has been measured in cultured PC 12 rat phaeochromocytoma cells. In the same way dopamine content in the medium after incubating these cells with or without NADH was assayed. The experiment shows that NADH is able to increase the activity of the tyrosine hydroxylase and dopamine - production in PC 12 cells up to 6 times. The results provide evidence that NADH is able to stimulate dopamine - biosynthesis directly.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Dopa Decarboxylase - antagonists and inhibitors
- Dopamine - biosynthesis
- Hydrazines - pharmacology
- NAD - pharmacology
- PC12 Cells - pharmacology
- Rats - pharmacology
- Stimulation, Chemical - pharmacology
- Tyrosine 3-Monooxygenase - metabolism
- Find related publications in this database (Keywords)
- Parkinsons Disease
- Tyrosine Hydroxylase
- Nicotinamide Adenine Dinucleotide (NADH)
- Dopamine
- PC-12 Cells