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Selected Publication:
Amann, R; Sirinathsinghji, DJ; Donnerer, J; Liebmann, I; Schuligoi, R.
Stimulation by nerve growth factor of neuropeptide synthesis in the adult rat in vivo: bilateral response to unilateral intraplantar injections.
Neurosci Lett. 1996; 203(3):171-174
Doi: 10.1016%2F0304-3940%2895%2912287-7
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- Leading authors Med Uni Graz
- Amann Rainer
- Co-authors Med Uni Graz
- Donnerer Josef
- Schuligoi Rufina
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- Abstract:
- Unilateral intraplantar injections (1/day for 3 days) of 4 mu g nerve growth factor (NGF) into the rat hindpaw increased the expression of prepro-tachykinin (PPT)- and prepro-calcitonin gene-related peptide (ppCGRP)-mRNA in bilateral L5 dorsal root ganglia (DRGs). This was accompanied by an increase of CGRP-like immunoreactivity in the ipsi- and contralateral sciatic nerve but by no detectable change of CGRP-IR in other afferents. NGF injections into the skin of one ear or into the plantar side of one forepaw increased CGRP-IR in the respective afferents (trigeminal ganglion, or nerves arising from the brachial plexus, respectively), but had no effect on sciatic CGRP-IR. This suggests that the NGF-induced symmetrical increase of CGRP synthesis in L5 DRGs was not caused by systemic action of NGF, which, therefore, may be a useful tool to further investigate mechanisms which are responsible for contralateral effects of unilateral inflammation.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Dose-Response Relationship, Drug -
- Ganglia, Spinal - metabolism
- In Situ Hybridization - metabolism
- Male - metabolism
- Nerve Growth Factors - pharmacology
- Neuropeptides - biosynthesis
- RNA, Messenger - metabolism
- Rats - metabolism
- Rats, Sprague-Dawley - metabolism
- Sciatic Nerve - metabolism
- Tachykinins - metabolism
- Find related publications in this database (Keywords)
- Dorsal Root Ganglion
- In Situ Hybridization Histochemistry
- Nerve Growth Factor
- Neuropeptides
- Rat