Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Fuchs, D; Samsonov, M; Tilz, GP; Reibnegger, G; Belenkov, JN; Nassonov, EL; Wachter, H.
Stimulated cellular immune system in patients with congestive heart failure.
Eur J Clin Chem Clin Biochem. 1993; 31(3):111-114
Doi: 10.1515/cclm.1993.31.3.111
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- Co-Autor*innen der Med Uni Graz
- Reibnegger Gilbert
- Tilz Gernot
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- Abstract:
- In this cross-sectional study, we analysed serum concentrations of soluble markers of cellular immune activation, namely, interferon-gamma, neopterin (a product of activated macrophages), soluble interleukin-2 receptor, and soluble CD8, in 25 patients with congestive heart failure. Ten (40%) patients showed increased concentrations (i.e. above the reference ranges of healthy controls) of neopterin, 14 (56%) showed increased soluble interleukin-2 receptor, and 6 (24%) showed increased soluble CD8. Endogenous interferon-gamma was detectable in 10 patients (40%). In addition, we found significant correlations between neopterin and interferon-gamma (rs = 0.417, p < 0.05), and between neopterin and soluble CD8 concentrations (rs = 0.430, p < 0.05). All patients with increased soluble CD8 also had increased soluble interleukin-2 receptor. However, no significant correlations of soluble interleukin-2 receptor with soluble CD8 or any of the other quantities were observed. Increased concentrations of soluble interleukin-2 receptors, soluble CD8 and neopterin indicate that cellular immunity is stimulated in patients with congestive heart failure. Activated CD8-positive T-lymphocytes may represent the source of increased soluble CD8. Endogenous interferon-gamma, which is derived from activated T-cells, may induce neopterin release by monocytes/macrophages.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Antigens, CD8 - blood
- Biological Markers - blood
- Biopterin - analogs and derivatives
- Heart Failure, Congestive - immunology
- Humans - immunology
- Immunity, Cellular - immunology
- Interferon Type II - blood
- Male - blood
- Middle Aged - blood
- Neopterin - blood
- Radioimmunoassay - blood
- Receptors, Interleukin-2 - analysis