Medizinische Universität Graz - Research portal

Go directly to the nagivation.
Go directly to the content.

Navigation/Search

Selected Publication:

Stoschitzky, K; Lindner, W; Klein, W.
Stereoselective release of (S)-atenolol from adrenergic nerve endings at exercise.
Lancet. 1992; 340(8821):696-697 Doi: 10.1016/0140-6736(92)92233-6
Web of Science PubMed FullText FullText_MUG Google Scholar

Leading authors Med Uni Graz: Stoschitzky Kurt
Altmetrics:
Dimensions Citations:
Plum Analytics:
Scite (citation analytics):
Abstract:: In-vitro studies have shown that atenolol, a beta-blocking agent, is stereoselectively taken up by and released from adrenergic nerve endings by membrane depolarisation. To investigate the potential importance of these findings, blood samples were taken at rest and after exercise testing from 10 patients (mean [SE] age 60 [3] years) receiving long-term treatment with racemic atenolol. At rest, mean plasma concentration of (R)-atenolol was higher than that of (S)-atenolol (ratio 1.14, p less than 0.01), but after exercise there was a stereoselective increase in (S)-atenolol concentration, which changed the ratio to 0.66 (p less than 0.01). Since (S)-atenolol but not (R)-atenolol causes clinically relevant beta-blockade, our findings may have importance for the management of patients receiving beta-blocking drugs.
Find related publications in this database (using NLM MeSH Indexing): Adrenergic Fibers - metabolism; Atenolol - blood; Chromatography, High Pressure Liquid - blood; Coronary Disease - drug therapy; Exercise Test - drug therapy; Humans - drug therapy; Middle Aged - drug therapy; Stereoisomerism - drug therapy