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Leis, HJ; Gleispach, H; Windischhofer, W.
Stable-Isotope Labeling and Quantitative-Determination of Enalaprilate in Human Plasma by GC-Nici-MS
J MASS SPECTROMETRY. 1995; 30: 1447-1452. Doi: 10.1002/jms.1190301010
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Leading authors Med Uni Graz: Leis Hans-Joerg
Co-authors Med Uni Graz: Windischhofer Werner
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Abstract:: A method for the quantitative determination of enalaprilate, the active metabolite of the angiotensin-converting enzyme inhibitor enalapril, is presented. The assay is based on gas chromatography-negative ion chemical ionization-mass spectrometry. The preparation of O-18(4)-labelled enalaprilate for use as an internal standard is described. The method involves solid phase extraction and derivation to the pentafluorobenzyl diestertrifluoroacetamide derivatives. The detection limit was found to be 0.5 pg, and, a lower limit of quantitation was reached down to 40 pg ml(-1) plasma. The method was applied to pharmacokinetics of the metabolite in humans.