Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Leis, HJ; Leis, M; Windischhofer, W.
Stable isotope labelling and determination of ketroprofen in human plasma and urine by gas chromatography/negative ion chemical ionization mass spectrometry.
J Mass Spectrom. 1996; 31(5):486-492
Doi: 10.1002/(SICI)1096-9888(199605)31:5<486::AID-JMS321>3.0.CO;2-L
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PubMed
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- Führende Autor*innen der Med Uni Graz
- Leis Hans-Joerg
- Co-Autor*innen der Med Uni Graz
- Windischhofer Werner
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- Abstract:
- A method for the quantitative measurement of the non-steroidal anti-inflammatory drug ketoprofen in human plasma and urine is presented. The assay is based on gas chromatography/negative ion chemical ionization mass spectrometry. The preparation of stable isotope-labelled ketoprofen for use as an internal standard is described. After solvent extraction from the acidified matrix, urine samples were analysed as pentafluorobenzyl esters, whereas plasma samples required further derivatization to the hydroxylamine-trimethylsilyl derivatives. The detection limit was found to be 5 pg in both cases. The method was applied to the pharmacokinetics of ketoprofen in man after epidermal application.
- Find related publications in this database (using NLM MeSH Indexing)
- Administration, Topical -
- Anti-Inflammatory Agents, Non-Steroidal - administration and dosage
- Calibration - administration and dosage
- Deuterium - administration and dosage
- Gas Chromatography-Mass Spectrometry - administration and dosage
- Humans - administration and dosage
- Indicators and Reagents - administration and dosage
- Isotope Labeling - administration and dosage
- Ketoprofen - administration and dosage
- Oxygen Isotopes - administration and dosage
- Skin Absorption - administration and dosage
- Find related publications in this database (Keywords)
- Ketoprofen
- Nonsteroidal Antiinflammatory Drugs
- Gas Chromatography Negative Ion Chemical Ionization Mass Spectrometry
- Drug Analysis