Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Dworschak, M; Franz, M; Hallström, S; Semsroth, S; Gasser, H; Haisjackl, M; Podesser, BK; Malinski, T.
S-nitroso human serum albumin improves oxygen metabolism during reperfusion after severe myocardial ischemia.
PHARMACOLOGY 2004 72: 106-112.
Doi: 10.1159/000079139
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- Hallström Seth
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- Abstract:
- Nitric oxide (NO) supplementation may modify myocardial oxygen consumption and vascular function after ischemia. We investigated the effects of the NO donor, S-nitroso human serum albumin (S-NO-HSA), on cardiac oxygen metabolism during controlled reperfusion on normothermic cardiopulmonary bypass after severe myocardial ischemia. Pigs randomly received either S-NO-HSA or human serum albumin prior to and throughout global myocardial ischemia. Myocardial oxygen utilization is impaired at the onset of reperfusion, which is not amenable to S-NO-HSA. However, NO supplementation during ongoing supply dependency of oxygen consumption eventually leads to greater myocardial oxygen delivery and consumption. In conjunction with a better washout of lactate, this indicates an improved capillary perfusion in the S-NO-HSA group during reperfusion, which results in a better contractile function post bypass.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Comparative Study -
- Coronary Circulation - drug effects
- Hemodynamic Processes - drug effects
- Humans - drug effects
- Myocardial Ischemia - metabolism
- Myocardial Reperfusion Injury - metabolism
- Myocardium - metabolism
- Nitric Oxide - metabolism
- Nitric Oxide Donors - pharmacology
- Nitroso Compounds - pharmacology
- Oxygen Consumption - drug effects
- Prospective Studies - drug effects
- Research Support, Non-U.S. Gov't - drug effects
- Serum Albumin, Bovine - pharmacology
- Swine - pharmacology
- Find related publications in this database (Keywords)
- heart preservation
- ischemia/reperfusion
- controlled reperfusion
- myocardial blood flow
- myocardial oxygen metabolism
- nitric oxide
- postischemic contractile function