Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Oettl, K; Dikalov, S; Freisleben, HJ; Mlekusch, W; Reibnegger, G.
Spin trapping study of antioxidant properties of neopterin and 7,8-dihydroneopterin.
Biochem Biophys Res Commun. 1997; 234(3):774-778
Doi: 10.1006/bbrc.1997.6712
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- Führende Autor*innen der Med Uni Graz
- Öttl Karl
- Co-Autor*innen der Med Uni Graz
- Reibnegger Gilbert
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- Abstract:
- Previously, it has been shown that pteridine derivatives are capable of modulating the action of free radicals and both prooxidant and antioxidant properties have been described. However, the mechanism of manifestation of these properties is still unclear. We studied the radical scavenging properties of 7,8-dihydroneopterin and neopterin using the spin trap 5,5-dimethyl-1-pyrroline-1-oxide (DMPO). It was found that dihydroneopterin acts generally as a radical scavenger. In the presence of dihydroneopterin the ESR signal was reduced by 30 to 90% compared to the control signal. The rate constants for the reactions of 7,8-dihydroneopterin with superoxide (10(3) M(-1) s(-1)) and peroxyl radicals (10(7) M(-1) s(-1)) were determined. Neopterin in contrast showed no reduction of the ESR signal except with superoxide radicals produced by xanthine oxidase. However, this effect was shown to be due to an inhibition of enzyme rather than to radical scavenging. Our results provide a basis for understanding previous observations of radical scavenger activity of 7,8-dihydroneopterin.
- Find related publications in this database (using NLM MeSH Indexing)
- Antioxidants - chemistry
- Biopterin - analogs and derivatives
- Electron Spin Resonance Spectroscopy - analogs and derivatives
- Kinetics - analogs and derivatives
- Neopterin - analogs and derivatives
- Oxidation-Reduction - analogs and derivatives
- Peroxides - chemistry
- Pteridines - chemistry
- Spin Labels - chemistry
- Superoxides - chemistry