Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Auner, HW; Klintschar, M; Crevenna, R; Beham-Schmid, C; Hoefler, G; Mitterbauer, G; Linkesch, W; Sill, H.
Two case studies of chronic idiopathic neutropenia preceding acute myeloid leukaemia.
Br J Haematol. 1999; 105(2):431-433
Doi: 10.1046%2Fj.1365-2141.1999.01322.x
(- Case Report)
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- Führende Autor*innen der Med Uni Graz
- Sill Heinz
- Co-Autor*innen der Med Uni Graz
- Beham-Schmid Christine
- Höfler Gerald
- Linkesch Werner
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- Abstract:
- Chronic idiopathic neutropenia is regarded as a benign disorder without risk of malignant transformation. We present two patients with chronic idiopathic neutropenia who showed disease progression to acute myeloid leukaemia. Sequence analysis of the granulocyte-colony stimulating factor receptor (G-CSFR) gene from leukaemic DNA did not reveal any mutations and microsatellite analysis provided no evidence of microsatellite instability or loss of constitutional heterozygosity. These case studies suggest that chronic idiopathic neutropenia may constitute a preleukaemic condition in some patients. Alterations of the G-CSFR or defective DNA mismatch repair do not appear to be involved in malignant transformation.
- Find related publications in this database (using NLM MeSH Indexing)
- Acute Disease -
- Aged -
- Cell Transformation, Neoplastic -
- Female -
- Humans -
- Leukemia, Myeloid - etiology
- Male - etiology
- Middle Aged - etiology
- Neutropenia - complications
- Pedigree - complications
- Receptors, Granulocyte Colony-Stimulating Factor - genetics
- Find related publications in this database (Keywords)
- Chronic Idiopathic Neutropenia
- Acute Myeloid Leukemia
- Granulocyte-Colony Stimulating Factor Receptor
- Microsatellites
- Cancer Predisposition