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Selected Publication:
Abuja, PM; Liebmann, P; Hayn, M; Schauenstein, K; Esterbauer, H.
Antioxidant role of melatonin in lipid peroxidation of human LDL.
FEBS LETT 1997 413: 289-293.
Doi: 10.1016%2FS0014-5793%2897%2900918-6
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- Leading authors Med Uni Graz
- Abuja Peter Michael
- Co-authors Med Uni Graz
- Liebmann-Holzmann Peter
- Schauenstein Konrad
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- Abstract:
- The antioxidant effect of melatonin on LDL oxidation was studied in vitro using either a thermolabile initiator or copper ions to induce lipid peroxidation. Loading of LDL with melatonin showed only weak protection against oxidative damage as compared to alpha-tocopherol. In the presence of high concentrations of melatonin (1000 mol/mol LDL) in the medium a clear protective effect was found during lag- and propagation phase, albeit weaker than after loading with alpha-tocopherol. It is concluded that melatonin is not incorporated into LDL in sufficient concentrations to prevent lipid peroxidation effectively. When melatonin is present in the incubation medium during oxidation, a partitioning equilibrium between aqueous and lipid phase is established. Only under these conditions can melatonin act as a chain breaking antioxidant. The concentrations required, however, are far beyond those found in human plasma. Therefore, the data in this study do not support a direct physiological relevance of melatonin as an antioxidant in lipid peroxidation processes.
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